Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling time series of finite life span and immortal non-malignant human mammary epithelial cell lines


ABSTRACT: We analyzed gene expression in 184 (finite life span) and HMT3522 S1 (immortal non-malignant) HMECs on successive days (3, 5, and 7) post-seeding in a laminin-rich extracellular matrix assay. Both HMECs underwent growth arrest in G0/G1 and differentiated into polarized acini between days 5 and 7.

ORGANISM(S): Homo sapiens

SUBMITTER: Katherine Martin 

PROVIDER: E-MEXP-1006 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer.

Fournier Marcia V MV   Martin Katherine J KJ   Kenny Paraic A PA   Xhaja Kris K   Bosch Irene I   Yaswen Paul P   Bissell Mina J MJ  

Cancer research 20060701 14


Nonmalignant human mammary epithelial cells (HMEC) seeded in laminin-rich extracellular matrix (lrECM) form polarized acini and, in doing so, transit from a disorganized proliferating state to an organized growth-arrested state. We hypothesized that the gene expression pattern of organized and growth-arrested HMECs would share similarities with breast tumors with good prognoses. Using Affymetrix HG-U133A microarrays, we analyzed the expression of 22,283 gene transcripts in 184 (finite life span)  ...[more]

Similar Datasets

2008-06-15 | E-GEOD-8096 | biostudies-arrayexpress
2012-02-29 | E-GEOD-35165 | biostudies-arrayexpress
2014-06-03 | E-GEOD-58151 | biostudies-arrayexpress
2007-05-02 | E-TABM-244 | biostudies-arrayexpress
2014-09-16 | E-GEOD-61433 | biostudies-arrayexpress
2014-10-02 | E-MTAB-2969 | biostudies-arrayexpress
2020-09-16 | PXD017649 | Pride
2014-04-25 | E-GEOD-57072 | biostudies-arrayexpress
2020-08-20 | E-MTAB-8254 | biostudies-arrayexpress
2015-12-10 | E-GEOD-75863 | biostudies-arrayexpress