Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Katherine Martin
PROVIDER: E-MEXP-1006 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Fournier Marcia V MV Martin Katherine J KJ Kenny Paraic A PA Xhaja Kris K Bosch Irene I Yaswen Paul P Bissell Mina J MJ
Cancer research 20060701 14
Nonmalignant human mammary epithelial cells (HMEC) seeded in laminin-rich extracellular matrix (lrECM) form polarized acini and, in doing so, transit from a disorganized proliferating state to an organized growth-arrested state. We hypothesized that the gene expression pattern of organized and growth-arrested HMECs would share similarities with breast tumors with good prognoses. Using Affymetrix HG-U133A microarrays, we analyzed the expression of 22,283 gene transcripts in 184 (finite life span) ...[more]