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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of Gcn5 and Ada2a mutant Drosophila larve

ABSTRACT: Comparison of transcript profiling in Gcn5 and Ada2a drosophila mutant larve, with previously published transcript profiling in Nurf301 mutants (Badenhorst, P. et al. Genes Dev 19, 2540-5, 2005).

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Christophe Antoniewski

PROVIDER: E-MEXP-1208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization.

Carré Clément C Ciurciu Anita A Komonyi Orbán O Jacquier Caroline C Fagegaltier Delphine D Pidoux Josette J Tricoire Hervé H Tora Laszlo L Boros Imre M IM Antoniewski Christophe C

EMBO reports 20071214 2

Drosophila Gcn5 is the catalytic subunit of the SAGA and ATAC histone acetylase complexes. Here, we show that mutations in Gcn5 and the ATAC component Ada2a induce a decondensation of the male X chromosome, similar to that induced by mutations in the Iswi and Nurf301 subunits of the NURF nucleosome remodelling complex. Genetic studies as well as transcript profiling analysis indicate that ATAC and NURF regulate overlapping sets of target genes during development. In addition, we find that Ada2a ...[more]

PMID: 18084186

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