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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human Rhabdomyosarcoma biopsy samples (15 embryonal RMS, 10 translocation-positive alveolar RMS and 5 translocation-negative alveolar RMS)

ABSTRACT: We measured the expression profiles of a series of 30 Rhabdomyosarcoma biopsy samples (15 embryonal RMS, 10 translocation-positive alveolar RMS and 5 translocation-negative alveolar RMS). Expression data was used for unsupervised hierarchical clustering as well as supervised analysis to find gene expression signatures characteristic for the different histological RMS subgroups.

ORGANISM(S): Homo sapiens

DISEASE(S): alveolar rhabdomyosarcoma

SUBMITTER: Beat Schafer

PROVIDER: E-MEXP-121 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression signatures identify rhabdomyosarcoma subtypes and detect a novel t(2;2)(q35;p23) translocation fusing PAX3 to NCOA1.

Wachtel Marco M Dettling Marcel M Koscielniak Eva E Stegmaier Sabine S Treuner Jörn J Simon-Klingenstein Katja K Bühlmann Peter P Niggli Felix K FK Schäfer Beat W BW

Cancer research 20040801 16

Rhabdomyosarcoma is a pediatric tumor type, which is classified based on histological criteria into two major subgroups, namely embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma. The majority, but not all, alveolar rhabdomyosarcoma carry the specific PAX3(7)/FKHR-translocation, whereas there is no consistent genetic abnormality recognized in embryonal rhabdomyosarcoma. To gain additional insight into the genetic characteristics of these subtypes, we used oligonucleotide microarrays to mea ...[more]

PMID: 15313887

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