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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human CD14+ CD16- and CD14low CD16+ monocytes from patients with Sjogrens syndrome and normal controls

ABSTRACT: Sjogren's syndrome is an autoimmune disease, characterized by complaints such as xerostomia and keratoconjunctivitis sicca. In other autoimmune diseases such as diabetes and SLE, monocyte abberancies have been described. Therefore, this study aimed at studying the monocyte compartment in Sjogren's Syndrome, by transcription profiling of CD14+CD16- and CD14lowCD16+ monocytes in patients and controls.

ORGANISM(S): Homo sapiens

DISEASE(S): Sjogren's syndrome

SUBMITTER: Manon Wildenberg

PROVIDER: E-MEXP-1242 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Systemic increase in type I interferon activity in Sjögren's syndrome: a putative role for plasmacytoid dendritic cells.

Wildenberg Manon E ME van Helden-Meeuwsen Cornelia G CG van de Merwe Joop P JP Drexhage Hemmo A HA Versnel Marjan A MA

European journal of immunology 20080701 7

In the salivary glands of primary Sjögren's syndrome (pSjS) patients, type I IFN activity is increased, but systemic levels of type I IFN proteins are rarely detected. This study focused on the systemic activity of type I IFN in pSjS, as well as the role of peripheral plasmacytoid dendritic cells (pDC). Monocytes obtained from pSjS patients showed an increased expression of 40 genes. Twenty-three of these genes (58%), including IFI27, IFITM1, IFIT3 and IFI44, were inducible by type I IFN. pSjS s ...[more]

PMID: 18581327

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2011-05-01 | E-GEOD-25913 | biostudies-arrayexpress

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Project description:A study was designed to further define the viral landscape within Sjogren's Syndrome (pSS) affected salivary gland tissue to identify potential viral-mediated triggers in the pathogenesis of this autoimmune disease.

2017-05-01 | GSE77599 | GEO

Viral Profiles in Sjogren's Syndrome

2017-05-01 | E-GEOD-77599 | biostudies-arrayexpress

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2016-02-25 | E-MTAB-3554 | biostudies-arrayexpress

Chronic psoriatic skin inflammation leads to increased monocyte adhesion and aggregation

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Transcription profiling of CD14 monocytyes and CD16 neutrophils from patients with systemic lupus erythematosus

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