Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Ewg differentially regulated genes

ABSTRACT: Ewg differentially regulated genes in 16-18 h Drosophila embryos. The experiment contains expression measurements from wild type, ewg l1 protein null allele and ewg l1 elavEWG (elavEWG rescue construct expressing a ewg cDNA from the elav promoter) mutants.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Matthias Soller 

PROVIDER: E-MEXP-1312 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathways.

Haussmann Irmgard U IU   White Kalpana K   Soller Matthias M  

Genome biology 20080417 4

<h4>Background</h4>Formation of synaptic connections is a dynamic and highly regulated process. Little is known about the gene networks that regulate synaptic growth and how they balance stimulatory and restrictive signals.<h4>Results</h4>Here we show that the neuronally expressed transcription factor gene erect wing (ewg) is a major target of the RNA binding protein ELAV and that EWG restricts synaptic growth at neuromuscular junctions. Using a functional genomics approach we demonstrate that E  ...[more]

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