Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of mouse mammary epithelial cells NMuMG treatd with TGF-b1 - time series experiment

ABSTRACT: Response of mouse mammary epithelial cells NMuMG to TGF-b1 - time course experiment. Identification of novel gene targets involved in TGF-b1-driven regulation of epithelial-mesenchymal transition (EMT).

INSTRUMENT(S): microcentrifuge

ORGANISM(S): Mus musculus

SUBMITTER: Ulrich Valcourt

PROVIDER: E-MEXP-139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition.

Valcourt Ulrich U Kowanetz Marcin M Niimi Hideki H Heldin Carl-Henrik CH Moustakas Aristidis A

Molecular biology of the cell 20050202 4

Epithelial-mesenchymal transition (EMT) contributes to normal tissue patterning and carcinoma invasiveness. We show that transforming growth factor (TGF)-beta/activin members, but not bone morphogenetic protein (BMP) members, can induce EMT in normal human and mouse epithelial cells. EMT correlates with the ability of these ligands to induce growth arrest. Ectopic expression of all type I receptors of the TGF-beta superfamily establishes that TGF-beta but not BMP pathways can elicit EMT. Ectopic ...[more]

PMID: 15689496

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Dataset Information

Transcription profiling of mouse mammary epithelial cells NMuMG treatd with TGF-b1 - time series experiment

Publications

TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition.

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