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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of fat biopsies from monozygotic twins discordant for body mass index to elucidate the effects of acquired obesity

ABSTRACT: Elucidating the effects of acquired obesity by comparison of fat biopsies from monozygotic twins discordant for BMI.

ORGANISM(S): Homo sapiens

SUBMITTER: Jussi Naukkarinen

PROVIDER: E-MEXP-1425 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity.

Pietiläinen Kirsi H KH Naukkarinen Jussi J Rissanen Aila A Saharinen Juha J Ellonen Pekka P Keränen Heli H Suomalainen Anu A Götz Alexandra A Suortti Tapani T Yki-Järvinen Hannele H Oresic Matej M Kaprio Jaakko J Peltonen Leena L

PLoS medicine 20080301 3

<h4>Background</h4>The acquired component of complex traits is difficult to dissect in humans. Obesity represents such a trait, in which the metabolic and molecular consequences emerge from complex interactions of genes and environment. With the substantial morbidity associated with obesity, a deeper understanding of the concurrent metabolic changes is of considerable importance. The goal of this study was to investigate this important acquired component and expose obesity-induced changes in bio ...[more]

PMID: 18336063

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