Transcription profiling of mouse embryos with induced mutations XpO vs XmO
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Simon Andrews
PROVIDER: E-MEXP-145 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice.
Davies William W Isles Anthony A Smith Rachel R Karunadasa Delicia D Burrmann Doreen D Humby Trevor T Ojarikre Obah O Biggin Carol C Skuse David D Burgoyne Paul P Wilkinson Lawrence L
Nature genetics 20050522 6
Imprinted genes show differential expression between maternal and paternal alleles as a consequence of epigenetic modification that can result in 'parent-of-origin' effects on phenotypic traits. There is increasing evidence from mouse and human studies that imprinted genes may influence behavior and cognitive functioning. Previous work in girls with Turner syndrome (45,XO) has suggested that there are X-linked parent-of-origin effects on brain development and cognitive functioning, although the ...[more]
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