Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

42 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of A.thaliana to determine the ffect of aneuplody extra copy of chromosome 5

ABSTRACT: Effects of aneuploidy on gene expression in Arabidopsis thaliana containing extra copies of chromosome 5.

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Bruno Huettel

PROVIDER: E-MEXP-1454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Effects of aneuploidy on genome structure, expression, and interphase organization in Arabidopsis thaliana.

Huettel Bruno B Kreil David P DP Matzke Marjori M Matzke Antonius J M AJ

PLoS genetics 20081017 10

Aneuploidy refers to losses and/or gains of individual chromosomes from the normal chromosome set. The resulting gene dosage imbalance has a noticeable affect on the phenotype, as illustrated by aneuploid syndromes, including Down syndrome in humans, and by human solid tumor cells, which are highly aneuploid. Although the phenotypic manifestations of aneuploidy are usually apparent, information about the underlying alterations in structure, expression, and interphase organization of unbalanced c ...[more]

PMID: 18927630

Similar Datasets

Transcription profiling of heat stress response in Arabidopsis wild type and hsf1x3 double knockout mutant lines

Project description:The aim of the expression profiling was to define and to apply criteria that allow discrimination between the effects of heat stress (HS) and HSF-dependent gene expression in Arabidopsis. Therefore we determined and analyzed the expression profiles of wild type (WT) and homozygous hsf1--/hsf3-- double knock out mutant plants (abbreviated hsf1/3). Hsf1/3 plants are deficient in HSF1 and HSF3 activity and unable to induce the fast transient expression of mRNAs of a number of HS genes tested (Lohmann et al., 2004).<br> The effects of HS on gene expression were analyzed after one hour heat treatment (37C) of leaf tissue.

2004-12-15 | E-MEXP-98 | biostudies-arrayexpress

Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice.

Project description:Obesity-associated insulin resistance is characterized by a state of chronic, low-grade inflammation that is associated with the accumulation of M1 proinflammatory macrophages in adipose tissue. Although different evidence explains the mechanisms linking the expansion of adipose tissue and adipose tissue macrophage (ATM) polarization, in the current study we investigated the concept of lipid-induced toxicity as the pathogenic link that could explain the trigger of this response. We addressed this question using isolated ATMs and adipocytes from genetic and diet-induced murine models of obesity. Through transcriptomic and lipidomic analysis, we created a model integrating transcript and lipid species networks simultaneously occurring in adipocytes and ATMs and their reversibility by thiazolidinedione treatment. We show that polarization of ATMs is associated with lipid accumulation and the consequent formation of foam cell–like cells in adipose tissue. Our study reveals that early stages of adipose tissue expansion are characterized by M2-polarized ATMs and that progressive lipid accumulation within ATMs heralds the M1 polarization, a macrophage phenotype associated with severe obesity and insulin resistance. Furthermore, rosiglitazone treatment, which promotes redistribution of lipids toward adipocytes and extends the M2 ATM polarization state, prevents the lipid alterations associated with M1 ATM polarization. Our data indicate that the M1 ATM polarization in obesity might be a macrophage-specific manifestation of a more general lipotoxic pathogenic mechanism. This indicates that strategies to optimize fat deposition and repartitioning toward adipocytes might improve insulin sensitivity by preventing ATM lipotoxicity and M1 polarization. 15 samples; 2 genotypes and 2 time points

2012-03-22 | E-GEOD-36669 | biostudies-arrayexpress

LinX - software for evaluation of CX-MS data

Project description:Chemical cross-linking mass spectrometry data from analysis of N14/N15 labeled proteins

2021-03-11 | PXD023522 | Pride

Transcription profiling of BRCA1 wild type and mutant human breast tumors to examine expression of ER-alpha

Project description:Looking at the expression of ER alpha in BRCA1 and mutant tumours

2007-11-22 | E-TABM-366 | biostudies-arrayexpress

Transcription profiling of decidua basalis from women with normal pregnancies or preeclampsia and/or fetal growth restriction

Project description:The aim of the study was to compare gene expression profiles in decidua basalis from cases with complicated pregnancies to those from healthy pregnant controls. Cases included pregnant women with preeclampsia (PE) and/or fetal growth restriction (FGR). Decidual tissue was obtained by vacuum suction of the placental bed after the placenta was delivered. Women with PE and/or FGR were included as cases. PE was defined as persistent hypertension (blood pressure (BP) ¡Ý 140/90 mm Hg), plus proteinuria (¡Ý0.3g/24 h or ¡Ý2+ according to a dipstick test), developing after 20 weeks of pregnancy. FGR implied birth weight under 2 standard deviations (SD) below the expected birth weight, as related to gestational age (GA) and sex. Due to tissue sampling procedures, only cases delivered by cesarean section (CS) were included. Healthy women with normal pregnancies, undergoing CS for various reasons considered irrelevant to the aim of this study (e. g. breech presentation and previous CS), served as controls. Tissue was immediately submerged in a RNA stabilisation solution (RNAlater, Ambion, Huntingdon, U.K.), incubated at 4¡ãC overnight and stored at -80¡ãC

2007-08-31 | E-MEXP-1050 | biostudies-arrayexpress

Transcription profiling of Arabidopsis apices from control and smz-D flc-3 knock-out plants after photoperiod induction

Project description:Response of control (flc-3) and dominant late flowering mutant (smz-D flc-3) to inductive photoperiod (tissue: apices)

2009-06-05 | E-MEXP-2041 | biostudies-arrayexpress

Transcription profiling of Arabidopsis leaves from control and smz-D flc-3 knock-out plants after photoperiod induction

Project description:Response of Arabidopsis control (flc-3) and a dominant repressor of flowering (smz-D flc-3) to inductive photoperiod

2009-06-05 | E-MEXP-2040 | biostudies-arrayexpress

Hanley-Bowdoin ArabidopsisCaLCuV 12dpi

Project description:Effect of geminivirus Cabbage leaf curl virus on Arabidopsis Col-0 at 12 days post-inoculation during short day conditions.

2008-07-30 | E-ATMX-34 | biostudies-arrayexpress

Methylation profiling of human normal somatic tissues, placenta, sperm and an immortalized cell line to identify tissue-specific differentially methylated regions

Project description:Genome-wide DNA methylation reference profiles of 13 normal somatic tissues, placenta, sperm and an immortalized cell line using the meDIP technique and a custom oligonucleotide array targetting the vast majority of annotated TSSs and non-promoter CGIs in the human genome.

2008-04-30 | E-TABM-445 | biostudies-arrayexpress

Transcription profiling of four mouse tissues following acute caloric restriction

Project description:Multi-tissue transcriptional response following acute caloric restriction in mice.

2007-05-17 | E-MEXP-748 | biostudies-arrayexpress