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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of dicer knock-out nociceptive sensory neurons from mice to investigate the roles of microRNAs in nociception

ABSTRACT: We used the Nav1.8-Cre to delete Dicer in mouse nociceptive sensory neurons to investigate the roles of microRNAs in nociception.

ORGANISM(S): Mus musculus

SUBMITTER: Jing Zhao

PROVIDER: E-MEXP-1461 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds.

Zhao Jing J Lee Man-Cheung MC Momin Ali A Cendan Cruz-Miguel CM Shepherd Samuel T ST Baker Mark D MD Asante Curtis C Bee Lucy L Bethry Audrey A Perkins James R JR Nassar Mohammed A MA Abrahamsen Bjarke B Dickenson Anthony A Cobb Bradly S BS Merkenschlager Matthias M Wood John N JN

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100801 32

To examine the role of small RNAs in peripheral pain pathways, we deleted the enzyme Dicer in mouse postmitotic damage-sensing neurons. We used a Nav1.8-Cre mouse to target those nociceptors important for inflammatory pain. The conditional null mice were healthy with a normal number of sensory neurons and normal acute pain thresholds. Behavioral studies showed that inflammatory pain was attenuated or abolished. Inflammatory mediators failed to enhance excitability of Nav1.8+ sensory neurons from ...[more]

PMID: 20702715

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