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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of mouse microvascular endothelial cells treated with FGF2

ABSTRACT: Effect of FGF2 on the transcriptional profile of microvascular endothelial cells

ORGANISM(S): Mus musculus

SUBMITTER: German Andres

PROVIDER: E-MEXP-1467 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A pro-inflammatory signature mediates FGF2-induced angiogenesis.

Andrés Germán G Leali Daria D Mitola Stefania S Coltrini Daniela D Camozzi Maura M Corsini Michela M Belleri Mirella M Hirsch Emilio E Schwendener Reto A RA Christofori Gerhard G Alcamì Antonio A Presta Marco M

Journal of cellular and molecular medicine 20090801 8B

Fibroblast growth factor-2 (FGF2) is a potent angiogenic growth factor. Here, gene expression profiling of FGF2-stimulated microvascular endothelial cells revealed, together with a prominent pro-angiogenic profile, a pro-inflammatory signature characterized by the upregulation of pro-inflammatory cytokine/chemokines and their receptors, endothelial cell adhesion molecules and members of the eicosanoid pathway. Real-time quantitative PCR demonstrated early induction of most of the FGF2-induced, i ...[more]

PMID: 18624773

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