Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparative genomic hybridization of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes


ABSTRACT: Genomic DNA of 61 strains of proteolytic Clostridium botulinum or Clostridium sporogenes was subjected to analysis by DNA microarray.

ORGANISM(S): Clostridium botulinum

SUBMITTER: Andrew Carter 

PROVIDER: E-MEXP-1637 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Independent evolution of neurotoxin and flagellar genetic loci in proteolytic Clostridium botulinum.

Carter Andrew T AT   Paul Catherine J CJ   Mason David R DR   Twine Susan M SM   Alston Mark J MJ   Logan Susan M SM   Austin John W JW   Peck Michael W MW  

BMC genomics 20090319


<h4>Background</h4>Proteolytic Clostridium botulinum is the causative agent of botulism, a severe neuroparalytic illness. Given the severity of botulism, surprisingly little is known of the population structure, biology, phylogeny or evolution of C. botulinum. The recent determination of the genome sequence of C. botulinum has allowed comparative genomic indexing using a DNA microarray.<h4>Results</h4>Whole genome microarray analysis revealed that 63% of the coding sequences (CDSs) present in re  ...[more]

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