Transcription profiling of pancreas from Wistar or WBN/Kob rats to study chronic pancreatitis
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ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Ulrich Wagner
PROVIDER: E-MEXP-1704 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Inflammation-dependent expression of SPARC during development of chronic pancreatitis in WBN/Kob rats and a microarray gene expression analysis.
Reding T T Wagner U U Silva A B AB Sun L-K LK Bain M M Kim S-Y SY Bimmler D D Graf R R
Physiological genomics 20090512 2
The pathophysiology of human chronic pancreatitis is not well understood and difficult to follow on a molecular basis. Therefore, we used a rat model [Wistar-Bonn/Kobori (WBN/Kob)] that exhibits spontaneous chronic inflammation and fibrosis in the pancreas. Using microarrays we compared gene expression patterns in the pancreas during development of inflammation and fibrosis of WBN/Kob rats with age-matched healthy Wistar rats. The extracellular matrix protein SPARC (secreted protein, acidic, and ...[more]
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