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Transcription profiling of human monocyte derived dendritic cells stimulated with different forms of a non pathogen S. cerevisiae strain

ABSTRACT: Stimulation of monocyte derived dendritic cells with different forms of a non pathogen Saccaromyces cerevisiae strain.

ORGANISM(S): Homo sapiens

SUBMITTER: Luca Beltrame

PROVIDER: E-MEXP-1745 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A systems biology approach to the mutual interaction between yeast and the immune system.

Rizzetto Lisa L Cavalieri Duccio D

Immunobiology 20100609 9-10

Dendritic cells (DCs) are capable of sensing fungi and then to initiate an appropriate defense against the invading microbe. We studied interactions between host and microorganism by analyzing the transcriptional response of DCs stimulated by the harmless Saccharomyces cerevisiae and of this phagocytosed fungus. Pathway analyses provided insight into the mutual interactions. Of particular interest was the responses elicited by the DC in the fungus, including downregulation of the carbon-compound ...[more]

PMID: 20646781

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