Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): glioblastoma
SUBMITTER: Sean Lawler
PROVIDER: E-MEXP-1796 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer research 20081101 22
MicroRNAs (miR) show characteristic expression signatures in various cancers and can profoundly affect cancer cell behavior. We carried out miR expression profiling of human glioblastoma specimens versus adjacent brain devoid of tumor. This revealed several significant alterations, including a pronounced reduction of miR-128 in tumor samples. miR-128 expression significantly reduced glioma cell proliferation in vitro and glioma xenograft growth in vivo. miR-128 caused a striking decrease in expr ...[more]