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MicroRNA profiling of human glioblastoma specimens and normal adjacent tissue

ABSTRACT: MicroRNA profiles were determined for surgically excised glioblastoma specimens and compared with normal adjacent tissue in the same patients

ORGANISM(S): Homo sapiens

DISEASE(S): glioblastoma

SUBMITTER: Sean Lawler

PROVIDER: E-MEXP-1796 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal.

Godlewski Jakub J Nowicki Michal O MO Bronisz Agnieszka A Williams Shanté S Otsuki Akihiro A Nuovo Gerard G Raychaudhury Abhik A Newton Herbert B HB Chiocca E Antonio EA Lawler Sean S

Cancer research 20081101 22

MicroRNAs (miR) show characteristic expression signatures in various cancers and can profoundly affect cancer cell behavior. We carried out miR expression profiling of human glioblastoma specimens versus adjacent brain devoid of tumor. This revealed several significant alterations, including a pronounced reduction of miR-128 in tumor samples. miR-128 expression significantly reduced glioma cell proliferation in vitro and glioma xenograft growth in vivo. miR-128 caused a striking decrease in expr ...[more]

PMID: 19010882

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