Dataset Information
Transcription profiling time series of human CD34+ stem cells differentiating into macrophage-like cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hang Dinh
PROVIDER: E-MEXP-1826 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions.
Journal of immunology (Baltimore, Md. : 1950) 20090601 12
In chronic inflammatory lesions macrophages are abundant and adapt to the low oxygen concentrations often present there. In low oxygen some cell types die by apoptosis, as reported for macrophage cell lines, while others survive better as they shift their metabolism to anaerobic glycolysis. It was found here that hypoxia prolongs the survival of murine bone marrow-derived macrophages, either in the absence or presence of low CSF-1 (M-CSF) concentrations. Although Akt activity increased in bone m ...[more]
