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Transcription profiling of B. cenocepacia K56-2 wildtype and cepR2 mutant

ABSTRACT: Comparative transcriptional profiling of B. cenocepacia K56-2 (wildtype) and K56-2cepR2b (cepR2 mutant of K56-2).

ORGANISM(S): Burkholderia cepacia

SUBMITTER: Eoin O'Grady

PROVIDER: E-MEXP-1935 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A Burkholderia cenocepacia orphan LuxR homolog is involved in quorum-sensing regulation.

Malott Rebecca J RJ O'Grady Eoin P EP Toller Jessica J Inhülsen Silja S Eberl Leo L Sokol Pamela A PA

Journal of bacteriology 20090206 8

Burkholderia cenocepacia utilizes quorum sensing to control gene expression, including the expression of genes involved in virulence. In addition to CepR and CciR, a third LuxR homolog, CepR2, was found to regulate gene expression and virulence factor production. All B. cenocepacia strains examined contained this orphan LuxR homolog, which was not associated with an adjacent N-acyl-homoserine lactone synthase gene. Expression of cepR2 was negatively autoregulated and was negatively regulated by ...[more]

PMID: 19201791

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