Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Xenopus tropicalis in response to infection by the chytrid Batrachochytrium dendrobatidis

ABSTRACT: Chytridiomycosis is an emerging infectious disease of amphibians caused by the chytrid Batrachochytrium dendrobatidis (Bd). The disease has been associated with global amphibian declines and is driving the species in the wild to extinction. Using DNA microarray technology we have analysed transcriptional changes in Xenopus tropicalis during the course (7 and 42 days) of infection by Bd under warm (26oC) and cold (18oC) temperatures.

ORGANISM(S): Xenopus tropicalis

DISEASE(S): B. dendrobatidis infection

SUBMITTER: Ming-Shi Li 

PROVIDER: E-MEXP-1936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Expression profiling the temperature-dependent amphibian response to infection by Batrachochytrium dendrobatidis.

Ribas Laia L   Li Ming-Shi MS   Doddington Benjamin J BJ   Robert Jacques J   Seidel Judith A JA   Kroll J Simon JS   Zimmerman Lyle B LB   Grassly Nicholas C NC   Garner Trenton W J TW   Fisher Matthew C MC  

PloS one 20091222 12

Amphibians are experiencing a panzootic of unprecedented proportions caused by the emergence of Batrachochytrium dendrobatidis (Bd). However, all species are not equally at risk of infection, and risk is further modified by environmental variables, specifically temperature. In order to understand how, and when, hosts mount a response to Bd we analysed infection dynamics and patterns of gene expression in the model amphibian species Silurana (Xenopus) tropicalis. Mathematical modelling of infecti  ...[more]

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