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Transcription profiling of rat neonatal ventricular cardiac mycocytes exposed to endothelin-1 and C3 toxin

ABSTRACT: Effects of C3 toxin on RNA profiles in neonatal rat ventricular cardiac myocytes exposed to endothelin-1 (1 h)

ORGANISM(S): Rattus norvegicus

SUBMITTER: Angela Clerk

PROVIDER: E-MEXP-1977 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.

Marshall Andrew K AK Barrett Oliver P T OP Cullingford Timothy E TE Shanmugasundram Achchuthan A Sugden Peter H PH Clerk Angela A

PloS one 20100402 4

<h4>Background</h4>Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in the response, but their relative significance in regulating the cardiomyocyte transcriptome is unknown. Our aim was to establish the significance of ERK1/2 and/or RhoA in the early cardiomyocyte transcriptomic response to endothelin-1.<h4>Meth ...[more]

PMID: 20368814

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