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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human liver in response to flucloxacilin-induced liver injury

ABSTRACT: Drug-induced liver injury (DILI) due to flucloxacillin is a rare but serious complication of treatment with this antimicrobial. The genetic basis of susceptibility is poorly understood as is the underlying molecular mechanism for disease. There is some evidence that flucloxacillin is a pregnane X receptor (PXR) agonist. The current study was concerned with investigating the relevance of PXR to flucloxacillin toxicity and with the identification of genes changing in expression in response to flucloxacillin.

ORGANISM(S): Homo sapiens

SUBMITTER: Dan Swan

PROVIDER: E-MEXP-2128 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Protein S-nitrosylation Restricts Xenobiotic Receptor PXR Hyperactivity and Ameliorates Acetaminophen-induced Liver Injury in Mice

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Project description:The aim of the study was to elucidate the effects of pregnane receptor X (PXR) activation by rifampicin on the mononuclear cell gene expression in vivo.

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