Transcription profiling of mouse naive T cells differentiated under TH1 and TH2 conditions
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Barbara Schraml
PROVIDER: E-MEXP-2153 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The AP-1 transcription factor Batf controls T(H)17 differentiation.
Schraml Barbara U BU Hildner Kai K Ise Wataru W Lee Wan-Ling WL Smith Whitney A-E WA Solomon Ben B Sahota Gurmukh G Sim Julia J Mukasa Ryuta R Cemerski Saso S Hatton Robin D RD Stormo Gary D GD Weaver Casey T CT Russell John H JH Murphy Theresa L TL Murphy Kenneth M KM
Nature 20090705 7253
Activator protein 1 (AP-1, also known as JUN) transcription factors are dimers of JUN, FOS, MAF and activating transcription factor (ATF) family proteins characterized by basic region and leucine zipper domains. Many AP-1 proteins contain defined transcriptional activation domains, but BATF and the closely related BATF3 (refs 2, 3) contain only a basic region and leucine zipper, and are considered to be inhibitors of AP-1 activity. Here we show that Batf is required for the differentiation of IL ...[more]
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