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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse embryonic fibroblasts expressing wild type and heterozygous Plk4

ABSTRACT: A microarray comparison was performed to identify genes over expressed in both wild type and heterozygous Plk4 MEFs

ORGANISM(S): Mus musculus

SUBMITTER: Alan Morettin

PROVIDER: E-MEXP-2161 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts.

Morettin Alan A Ward Alejandra A Nantais Jordan J Hudson John W JW

BMC genomics 20090716

<h4>Background</h4>The polo-like kinases (Plks) are a group of serine/threonine kinases which have roles in many aspects of cellular function including the regulation of mitotic activity and cellular stress responses. This study focuses on Plk4, the most divergent member of the Plk family, which is necessary for proper cellular proliferation. More specifically, alterations in Plk4 levels cause significantly adverse mitotic defects including abnormal centrosome duplication and aberrant mitotic sp ...[more]

PMID: 19607708

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