Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of human MCF7 cell line with siRNA mediated knockdown of CNOT7 and/or CNOT8 subunits of Ccr4-Not deadenylase compared to control

ABSTRACT: siRNA-mediated knockdown of CNOT7 and/or CNOT8 compared to control to study role in the regulation of gene expression by these factors.

ORGANISM(S): Homo sapiens

SUBMITTER: Sebastiaan Winkler

PROVIDER: E-MEXP-2218 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

Aslam Akhmed A Mittal Saloni S Koch Frederic F Andrau Jean-Christophe JC Winkler G Sebastiaan GS

Molecular biology of the cell 20090715 17

Accurate gene expression requires the precise control of mRNA levels, which are determined by the relative rates of nuclear (pre-)mRNA synthesis and processing, and cytoplasmic mRNA turnover. A key step in mRNA degradation is the removal of the poly(A) tail, which involves several deadenylases including components of the Ccr4-Not complex. Here, we focused on the role of the human paralogues CNOT7 (hCaf1/Caf1a) and CNOT8 (hPop2/Caf1b/Calif), which possess deadenylase activity mediated by DEDD nuc ...[more]

PMID: 19605561

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Dataset Information

Transcription profiling of human MCF7 cell line with siRNA mediated knockdown of CNOT7 and/or CNOT8 subunits of Ccr4-Not deadenylase compared to control

Publications

The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.

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