Transcription profiling of rat organotypic hippocampal cultures following mild or severe stretch injury
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ABSTRACT:
Mild (10%) and severe (50%) stretch injuries were delivered to rats organotypic hippocampal cultures and mRNA levels were analyzed at 24h. Despite the lack of significant cell death, there was more activation of complex cellular mechanisms following 10% stretch than 50%. IL-1? played a central role in molecular interactions of both injury groups but additional pathways of neurodegeneration involving RhoA were found in 50% stretch.
ORGANISM(S): Rattus norvegicus
SUBMITTER: Salvatore Pernagallo
PROVIDER: E-MEXP-2235 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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