Transcription profiling of human dendritic cell maturation revealed by integration of proteome and transcriptome at the pathway level
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Luca Beltrame
PROVIDER: E-MEXP-2290 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dominant processes during human dendritic cell maturation revealed by integration of proteome and transcriptome at the pathway level.
Buschow Sonja I SI Lasonder Edwin E van Deutekom Hanneke W M HW Oud Machteld M MM Beltrame Luca L Huynen Martijn A MA de Vries I Jolanda M IJ Figdor Carl G CG Cavalieri Duccio D
Journal of proteome research 20100401 4
Gene expression is commonly used to study the activation of dendritic cells (DCs) to identify proteins that determine whether these cells induce an immunostimulatory or tolerogenic immune response. RNA expression, however, does not necessarily predict protein abundance and often requires large numbers of experiments for statistical significance. Proteomics provides a direct view on protein expression but is costly and time consuming. Here, we combined a comprehensive quantitative proteome and tr ...[more]
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