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Transcription profiling of Burkholderia pseudomallei under salt stress and the effect on a type III secretion system

ABSTRACT: Effect of NaCl of gene expression in Burkholderia pseudomallei at two time points

ORGANISM(S): Burkholderia pseudomallei

SUBMITTER: Jon Cuccui

PROVIDER: E-MEXP-2302 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system.

Pumirat Pornpan P Cuccui Jon J Stabler Richard A RA Stevens Joanne M JM Muangsombut Veerachat V Singsuksawat Ekapot E Stevens Mark P MP Wren Brendan W BW Korbsrisate Sunee S

BMC microbiology 20100614

<h4>Background</h4>Burkholderia pseudomallei is the causative agent of melioidosis where the highest reported incidence world wide is in the Northeast of Thailand, where saline soil and water are prevalent. Moreover, recent reports indicate a potential pathogenic role for B. pseudomallei in cystic fibrosis lung disease, where an increased sodium chloride (NaCl) concentration in airway surface liquid has been proposed. These observations raise the possibility that high salinity may represent a fa ...[more]

PMID: 20540813

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