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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of embryonic abdominal wall from wild type, Pitx2 heterozygote and Pitx2 mutant mice

ABSTRACT: Total RNA from abdominal walls of E10.5 mouse embryos that were wild type, heterozygote, or mutant at the Pitx2 locus were compared.. Three biological replicates were tested for each of the three genotypes.

ORGANISM(S): Mus musculus

SUBMITTER: Michael Gross

PROVIDER: E-MEXP-2332 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Pitx2-dependent occupancy by histone deacetylases is associated with T-box gene regulation in mammalian abdominal tissue.

Hilton Traci T Gross Michael K MK Kioussi Chrissa C

The Journal of biological chemistry 20100203 15

The homeodomain transcription factor Pitx2 and the T-box transcription factors are essential for organogenesis. Pitx2 and T-box genes are induced by growth factors and function as transcriptional activators or repressors. Gene expression analyses on abdominal tissue were used to identify seven of the T-box genes of the genome as Pitx2 target genes in the abdomen at embryonic day.10.5. Pitx2 activated Tbx4, Tbx15, and Mga and repressed Tbx1, Tbx2, Tbx5, and Tbx6 expression. As expected, activated ...[more]

PMID: 20129917

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