Dataset Information
Genotyping of human glioma
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): glioma
SUBMITTER: Bernard Malfoy
PROVIDER: E-MEXP-2423 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Extrachromosomal amplification mechanisms in a glioma with amplified sequences from multiple chromosome loci.
Human molecular genetics 20100107 7
Accumulation of extrachromosomal DNA molecules (double minute) is often responsible for gene amplification in cancers, but the mechanisms leading to their formation are still largely unknown. By using quantitative PCR, chromosome walking, in situ hybridization on metaphase chromosomes and whole genome analysis, we studied a glioma containing four extrachromosomally amplified loci (7p11, 1q32.1, 5p15 and 9p2). Complex extrachromosomal DNA molecules were formed by the fusion of several syntenic or ...[more]
