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Transcription profiling of Candida albicans biofilm exposed to amphotericin B, fluconazole or two concentrations of caspofungin

ABSTRACT: 30h of growth biofilms in microfermentors were exposed to caspofungin 0.5 µg/ml, caspofungin 5 µg/ml, fluconazole 80 µg/ml or amphotericin B 8 µg/ml. Control and antifungal-exposed biofilms were recovered at t= 0, 30, 60 and 120 min post exposure to antifungal.

ORGANISM(S): Candida albicans

SUBMITTER: Tristan Rossignol

PROVIDER: E-MEXP-2436 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Interaction of Candida albicans biofilms with antifungals: transcriptional response and binding of antifungals to beta-glucans.

Vediyappan Govindsamy G Rossignol Tristan T d'Enfert Christophe C

Antimicrobial agents and chemotherapy 20100301 5

Candida albicans can form biofilms that exhibit elevated intrinsic resistance to various antifungal agents, in particular azoles and polyenes. The molecular mechanisms involved in the antifungal resistance of biofilms remain poorly understood. We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. Mature C. albicans biofilms grown under continuous flow were exposed for as long as 2 h to concentrations ...[more]

PMID: 20194705

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