Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcriptional profiling of mouse heat left ventricle after dfferential cardiac remodeling in preload versus afterload.

ABSTRACT: The effect of preload and afterload on the development of cardiac hypertrophy and functional phenotype in mice.

ORGANISM(S): Mus musculus

SUBMITTER: Georgios Kararigas

PROVIDER: E-MEXP-2498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differential cardiac remodeling in preload versus afterload.

Toischer Karl K Rokita Adam G AG Unsöld Bernhard B Zhu Wuqiang W Kararigas Georgios G Sossalla Samuel S Reuter Sean P SP Becker Alexander A Teucher Nils N Seidler Tim T Grebe Cornelia C Preuss Lena L Gupta Shamindra N SN Schmidt Kathie K Lehnart Stephan E SE Krüger Martina M Linke Wolfgang A WA Backs Johannes J Regitz-Zagrosek Vera V Schäfer Katrin K Field Loren J LJ Maier Lars S LS Hasenfuss Gerd G

Circulation 20100823 10

<h4>Background</h4>Hemodynamic load regulates myocardial function and gene expression. We tested the hypothesis that afterload and preload, despite similar average load, result in different phenotypes.<h4>Methods and results</h4>Afterload and preload were compared in mice with transverse aortic constriction (TAC) and aortocaval shunt (shunt). Compared with sham mice, 6 hours after surgery, systolic wall stress (afterload) was increased in TAC mice (+40%; P<0.05), diastolic wall stress (preload) ...[more]

PMID: 20733099

Publication: 1/2

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Dataset Information

Transcriptional profiling of mouse heat left ventricle after dfferential cardiac remodeling in preload versus afterload.

Publications

Differential cardiac remodeling in preload versus afterload.

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