Gene expression profiling in diabetic skeletal muscle

ABSTRACT: We determined the expression profiles in skeletal muscle from people with type 2 diabetes, first degree relatives, and healthy control individuals by microarray experiments. All subjects were Caucasian males and biopsies were taken after a controlled metabolic period of a two hour hyperinsulinemic euglycemic clamp. Our results show for the first time that insulin signaling is significantly downregulated in people with type 2 diabetes, whereas it is significantly upregulated in first degree relatives. Furthermore, we identify several new genes in skeletal muscle from first degree relatives that have an altered gene expression compared to healthy controls.

ORGANISM(S): Homo sapiens

SUBMITTER: Jane Palsgaard 

PROVIDER: E-MEXP-2559 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress