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ChIP-chip by array of yeast to monitor mobilization of transcriptional regulators in response to methyl methanesulfonate and heat shock

ABSTRACT: Monitoring mobilization of transcriptional regulators in response to methyl methanesulfonate and heat shock using ChIP-chip

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Sujana Ghosh

PROVIDER: E-MEXP-2614 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Sequential recruitment of SAGA and TFIID in a genomic response to DNA damage in Saccharomyces cerevisiae.

Ghosh Sujana S Pugh B Franklin BF

Molecular and cellular biology 20101018 1

Eukaryotic genes respond to their environment by changing the expression of selected genes. The question we address here is whether distinct transcriptional responses to different environmental signals elicit distinct modes of assembly of the transcription machinery. In particular, we examine transcription complex assembly by the stress-directed SAGA complex versus the housekeeping assembly factor TFIID. We focus on genomic responses to the DNA damaging agent methyl methanesulfonate (MMS) in com ...[more]

PMID: 20956559

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