Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human astrocytes derived from trisomic human embryonic stem cells


ABSTRACT: Astrocytes derived from normal and aneuploid human embryonic stem cells, along with CCF-STTG1 astrocytoma cell line, and using three biological replicates for each sample, were used to develop an in-vitro model system, to identify biomarkers for astrocytic cancer cells and premalignant stem-like progenitors.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Sailesh Gopalakrishna-Pillai 

PROVIDER: E-MEXP-2633 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Astrocytes derived from trisomic human embryonic stem cells express markers of astrocytic cancer cells and premalignant stem-like progenitors.

Gopalakrishna-Pillai Sailesh S   Iverson Linda E LE  

BMC medical genomics 20100427


<h4>Background</h4>Trisomic variants of human embryonic stem cells (hESCs) arise spontaneously in culture. Although trisomic hESCs share many properties with diploid hESCs, they also exhibit features of cancer stem cells. Since most hESC-based therapies will utilize differentiated derivatives, it is imperative to investigate the potential of trisomic hESCs to undergo malignant transformation during differentiation prior to their use in the clinical setting.<h4>Methods</h4>Diploid and trisomic hE  ...[more]

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