Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression of microRNAs and their target mRNAs in hESC-derived cardiomyocyte clusters and in heart tissue_microRNA_data


ABSTRACT: Parallel transcription profiling of cardiomyocyte clusters derived from human embryonic stem cells. Both mRNA (E-MEXP-2654) and miRNA (this experiment) transcription are measured and fetal and adult heart tissues are included as controls. This experiment was updated on 7th July 2011 to fix incorrect AH6 and FH3 files

ORGANISM(S): Homo sapiens

SUBMITTER: Jane Synnergren 

PROVIDER: E-MEXP-2655 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Expression of microRNAs and their target mRNAs in human stem cell-derived cardiomyocyte clusters and in heart tissue.

Synnergren Jane J   Améen Caroline C   Lindahl Anders A   Olsson Björn B   Sartipy Peter P  

Physiological genomics 20100914 10


Recent studies have shown that microRNAs (miRNAs) act as posttranscriptional regulators and that they play important roles during heart development and in cardiac function. Thus, they may provide new means of altering stem cell fate and differentiation processes. However, information about the correlation between global miRNA and mRNA expression in cardiomyocyte clusters (CMCs) derived from human embryonic stem cells (hESC) and in fetal and adult heart tissue is lacking. In the present study the  ...[more]

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