Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient

ABSTRACT: We compared gene expression profiles between asymptomatic and symptomatic atherosclerotic plaques from the same patient. This was accomplished by analyzing carotid plaques from four patients with bilateral high-grade carotid artery stenoses one being symptomatic (TIA or stroke) and the other asymptomatic.

ORGANISM(S): Homo sapiens

DISEASE(S): Internal Carotid Artery Stenosis (NCI Metathesaurus C0340569) has DiseaseStaging Asymptomatic

SUBMITTER: Petra Ijas

PROVIDER: E-MEXP-268 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques.

Ijäs Petra P Nuotio Krista K Saksi Jani J Soinne Lauri L Saimanen Eija E Karjalainen-Lindsberg Marja-Liisa ML Salonen Oili O Sarna Seppo S Tuimala Jarno J Kovanen Petri T PT Kaste Markku M Lindsberg Perttu J PJ

Arteriosclerosis, thrombosis, and vascular biology 20061109 1

<h4>Objective</h4>We studied by microarray analysis whether symptomatic and asymptomatic carotid plaques from the same patient differ in gene expression and whether the same changes are present in an independent sample set.<h4>Methods and results</h4>Carotid plaques from four patients with bilateral high-grade stenosis, one being symptomatic and the other asymptomatic, were analyzed on Affymetrix U95Av2 arrays. 33 genes showed >1.5-fold change between symptomatic and asymptomatic plaques in an i ...[more]

PMID: 17095719

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Dataset Information

Transcription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient

Publications

Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques.

Similar Datasets

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