Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of yeast wild type, xrn1, xrn1 upf1, xrn1 nmd2, and xrn1 upf3 strains to investigate mRNA decay


ABSTRACT: To determine the effects of inactivation of both the nosense-mediated mRNA decay pathway and the general 5' to 3' decay pathway on yeast mRNA decay, we compared the expression profiles of the wild-type, xrn1, xrn1 upf1, xrn1 nmd2, and xrn1 upf3 strains.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Shuyun Dong 

PROVIDER: E-MEXP-27 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast.

He Feng F   Li Xiangrui X   Spatrick Phyllis P   Casillo Ryan R   Dong Shuyun S   Jacobson Allan A  

Molecular cell 20031201 6


Transcripts regulated by the yeast nonsense-mediated and 5' to 3' mRNA decay pathways were identified by expression profiling of wild-type, upf1Delta, nmd2Delta, upf3Delta, dcp1Delta, and xrn1Delta cells. This analysis revealed that inactivation of Upf1p, Nmd2p, or Upf3p has identical effects on global RNA accumulation; inactivation of Dcp1p or Xrn1p exhibits both common and unique effects on global RNA accumulation but causes upregulation of only a small fraction of transcripts; and the majorit  ...[more]

Similar Datasets

2011-11-08 | E-MEXP-26 | biostudies-arrayexpress
2022-08-29 | E-MTAB-12110 | biostudies-arrayexpress
2024-10-23 | GSE193992 | GEO
2021-06-10 | MSV000087605 | MassIVE
2020-01-14 | GSE114605 | GEO
2023-07-27 | GSE235552 | GEO
2023-02-21 | GSE199744 | GEO
2023-02-21 | GSE202587 | GEO
2019-07-25 | GSE132725 | GEO
2023-07-27 | GSE235553 | GEO