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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human BeWo trophoblasts stimulated with Coxiella burnetii, the agent of Q fever

ABSTRACT: The transcriptional response of BeWo cells stimulated with C. burnetii was analyzed using microarrays covering the whole human genome.

ORGANISM(S): Homo sapiens

SUBMITTER: Yannick Le Priol

PROVIDER: E-MEXP-2800 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Coxiella burnetii, the agent of Q fever, replicates within trophoblasts and induces a unique transcriptional response.

Ben Amara Amira A Ghigo Eric E Le Priol Yannick Y Lépolard Catherine C Salcedo Suzana P SP Lemichez Emmanuel E Bretelle Florence F Capo Christian C Mege Jean-Louis JL

PloS one 20101214 12

Q fever is a zoonosis caused by Coxiella burnetii, an obligate intracellular bacterium typically found in myeloid cells. The infection is a source of severe obstetrical complications in humans and cattle and can undergo chronic evolution in a minority of pregnant women. Because C. burnetii is found in the placentas of aborted fetuses, we investigated the possibility that it could infect trophoblasts. Here, we show that C. burnetii infected and replicated in BeWo trophoblasts within phagolysosome ...[more]

PMID: 21179488

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