Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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VM-zfIFNg


ABSTRACT: Transcriptomic profile of zebrafish larvae microinjected with IFNg1 expression construct

ORGANISM(S): Danio rerio

SUBMITTER: Victoriano Mulero 

PROVIDER: E-MEXP-2948 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis.

López-Muñoz Azucena A   Sepulcre María P MP   Roca Francisco J FJ   Figueras Antonio A   Meseguer José J   Mulero Victoriano V  

Molecular immunology 20110226 9-10


In mammals, IFNγ is the only type II IFN member, whereas most bony fish species have two IFNγ genes, namely IFNγ1 and IFNγ2. We report that both zebrafish IFNγ genes were unable to protect zebrafish larvae against viral infection, despite the fact that they moderately induced the expression of antiviral genes, strongly induced pro-inflammatory and antigen processing and presentation genes, and increased neutrophil numbers. Although both zebrafish IFNγs induced a similar set of immune genes, IFNγ  ...[more]

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