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Unknown,Transcriptomics,Genomics,Proteomics

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FOXK2 promotes AP-1 mediated transcriptional regulation - transcription profiling FOXK2 induction

ABSTRACT: Transcription profiling of FOXK2 expression in HeLa cells from a stably integrated doxycyline-inducible EGFP-FOXK2 expression construct.

ORGANISM(S): Homo sapiens

SUBMITTER: Leo Zeef

PROVIDER: E-MEXP-3040 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation.

Ji Zongling Z Donaldson Ian J IJ Liu Jingru J Hayes Andrew A Zeef Leo A H LA Sharrocks Andrew D AD

Molecular and cellular biology 20111114 2

The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs. Here, we demonstrate that FOXK2 participates in combinatorial transcriptional control with the AP-1 transcription factor. FOXK2 binding regions are widespread throughout the genome and are often coassociated with AP-1 bi ...[more]

PMID: 22083952

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