Ontology highlight
ABSTRACT:
ORGANISM(S): Candida albicans
SUBMITTER: Tristan Rossignol
PROVIDER: E-MEXP-3084 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rossignol Tristan T Kelly Bridie B Dobson Curtis C d'Enfert Christophe C
Antimicrobial agents and chemotherapy 20110801 10
The 18-amino-acid cationic, tryptophan-rich ApoEdpL-W peptide derived from human ApoE apolipoprotein was shown to have antifungal activity against pathogenic yeasts of the Candida genus (except C. glabrata). ApoEdpL-W was active against planktonic cells and early-stage biofilms but less active against mature biofilms, possibly because of its affinity for extracellular matrix beta-glucans. Moreover, ApoEdpL-W absorbed to medically relevant materials partially prevented the formation of biofilms o ...[more]