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Transcription profiling of human colon cancer cell line - ligand independent control

ABSTRACT: Control experiment to confirm ligand independent effect on gene regulation by ERb in HT29 cells. The colon cancer cell lines do not express endogenous ER but is made ERb-expressing by lentiviral transduction of an ERb expression cassette. Introduction of ERb makes it possible to study the role and function of ERb in colon cancer as well as the impact ERb has on its own (in the absence of ERa).

ORGANISM(S): Homo sapiens

SUBMITTER: Karin Edvardsson

PROVIDER: E-MEXP-3176 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Estrogen receptor β induces antiinflammatory and antitumorigenic networks in colon cancer cells.

Edvardsson Karin K Ström Anders A Jonsson Philip P Gustafsson Jan-Åke JÅ Williams Cecilia C

Molecular endocrinology (Baltimore, Md.) 20110414 6

Several studies suggest estrogen to be protective against the development of colon cancer. Estrogen receptor β (ERβ) is the predominant estrogen receptor expressed in colorectal epithelium and is the main candidate to mediate the protective effects. We have previously shown that expression of ERβ reduces growth of colorectal cancer in xenografts. Little is known of the actions of ERβ and its effect on gene transcription in colon cancers. To dissect the processes that ERβ mediates and to investig ...[more]

PMID: 21493669

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