Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

HK_CIA_experiment

ABSTRACT: In previous studies, we identified the fungal macrocyclic lactone (S)-curvularin (SC) as an anti-inflammatory agent using a screening system detecting inhibitors of the Janus kinase/signal transducer and activator of transcription pathway. The objective of the present study was to investigate whether SC is able to decrease proinflammatory gene expression in an in vivo model of a chronic inflammatory disease. Therefore, the effects of SC and dexamethasone were compared in the model of collagen-induced arthritis (CIA) in mice. In addition to measuring the arthritis index (paw swelling) of the animals, we also performed whole genome microarray analyses to identify SC target genes and new therapeutic targets of SC.

ORGANISM(S): Mus musculus

SUBMITTER: Hartmut Kleinert

PROVIDER: E-MEXP-3180 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis.

Schmidt Nadine N Art Julia J Forsch Ingrid I Werner Anke A Erkel Gerhard G Jung Mathias M Horke Sven S Kleinert Hartmut H Pautz Andrea A

The Journal of pharmacology and experimental therapeutics 20120705 1

In previous studies, we identified the fungal macrocyclic lactone (S)-curvularin (SC) as an anti-inflammatory agent using a screening system detecting inhibitors of the Janus kinase/signal transducer and activator of transcription pathway. The objective of the present study was to investigate whether SC is able to decrease proinflammatory gene expression in an in vivo model of a chronic inflammatory disease. Therefore, the effects of SC and dexamethasone were compared in the model of collagen-in ...[more]

PMID: 22767531

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Dataset Information

HK_CIA_experiment

Publications

The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis.

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