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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Cited-1 deficiency suppresses intestinal tumorigenesis through the repression of the Wnt pathway- evidence for the just right model of Wnt mediated tumorigenesis

ABSTRACT: Comparison of the expression profiles of the following genetically altered murine intestinal epithelium: AhCre wildtype, AhCre Apc floxed, AhCre Cited1 null and Ahcre Apcflx/Cited1 null.

ORGANISM(S): Mus musculus

SUBMITTER: Lee Parry

PROVIDER: E-MEXP-3202 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cited1 deficiency suppresses intestinal tumorigenesis.

Méniel Valérie V Song Fei F Phesse Toby T Young Madeleine M Poetz Oliver O Parry Lee L Jenkins John R JR Williams Geraint T GT Dunwoodie Sally L SL Watson Alastair A Clarke Alan R AR

PLoS genetics 20130801 8

Conditional deletion of Apc in the murine intestine alters crypt-villus architecture and function. This process is accompanied by multiple changes in gene expression, including upregulation of Cited1, whose role in colorectal carcinogenesis is unknown. Here we explore the relevance of Cited1 to intestinal tumorigenesis. We crossed Cited1 null mice with Apc(Min/+) and AhCre(+)Apc(fl/fl) mice and determined the impact of Cited1 deficiency on tumour growth/initiation including tumour multiplicity, ...[more]

PMID: 23935526

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