Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse adult primary neural stem cells when stimulated with the proliferative agent PACAP (pituitary adenylate cyclase-activating polypeptide)

ABSTRACT: Investigation of transcriptional changes induced in adult primary neural stem cells when stimulated with the proliferative agent PACAP (pituitary adenylate cyclase-activating polypeptide). In addition the data was compared to results obtained from a proliferation control (stimulation with a transmembrane receptor agonist) and a differentiation control (primary neural stem cells induced to differentiate by withdrawing growth factors, adding serum and plating onto solid support).

ORGANISM(S): Mus musculus

SUBMITTER: Alex Mercer 

PROVIDER: E-MEXP-322 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Epidermal growth factor (EGF) withdrawal masks gene expression differences in the study of pituitary adenylate cyclase-activating polypeptide (PACAP) activation of primary neural stem cell proliferation.

Sievertzon Maria M   Wirta Valtteri V   Mercer Alex A   Frisén Jonas J   Lundeberg Joakim J  

BMC neuroscience 20050828

<h4>Background</h4>The recently discovered adult neural stem cells, which maintain continuous generation of new neuronal and glial cells throughout adulthood, are a promising and expandable source of cells for use in cell replacement therapies within the central nervous system. These cells could either be induced to proliferate and differentiate endogenously, or expanded and differentiated in culture before being transplanted into the damaged site of the brain. In order to achieve these goals ef  ...[more]

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