Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Leo Zeef
PROVIDER: E-MEXP-3230 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mendoza-Villanueva Daniel D Zeef Leo L Shore Paul P
Breast cancer research : BCR 20111027 5
<h4>Introduction</h4>Breast cancers frequently metastasise to the skeleton where they cause osteolytic bone destruction by stimulating osteoclasts to resorb bone and by preventing osteoblasts from producing new bone. The Runt-related transcription factor 2, Runx2, is an important determinant of bone metastasis in breast cancer. Runx2 is known to mediate activation of osteoclast activity and inhibition of osteoblast differentiation by metastatic breast cancer cells. However, while Runx2-regulated ...[more]