Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Taku Tokuyasu
PROVIDER: E-MEXP-3296 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
DeLay Michael M Jahangiri Arman A Carbonell W Shawn WS Hu Yu-Long YL Tsao Sean S Tom Maxwell Wing MW Paquette Jesse J Tokuyasu Taku A TA Aghi Manish K MK
Clinical cancer research : an official journal of the American Association for Cancer Research 20120403 10
<h4>Purpose</h4>To identify mechanisms and mediators of resistance to antiangiogenic therapy in human glioblastoma.<h4>Experimental design</h4>We carried out microarray gene expression analysis and immunohistochemistry comparing 21 recurrent glioblastomas progressing during antiangiogenic treatment with VEGF neutralizing antibody bevacizumab to paired pretreatment tumors from the same patients.<h4>Results</h4>Microarray analysis revealed that bevacizumab-resistant glioblastomas (BRG) had two clu ...[more]