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Zuklys etal_TECmRNA_DicerWT_vs_KO

ABSTRACT: mTEC and cTEC profiles from 2 week old Dicer fl/fl (WT) and Foxn1Cre::Dicer fl/fl mice. cTEC(CD45-EpCAM+MHCII+UEA-1-Ly51+) and mTEC(CD45-EpCAM+MHCII+UEA-1+Ly51-) were isolated from thymus tissue by cell sorting

ORGANISM(S): Mus musculus

SUBMITTER: Saulius Zuklys

PROVIDER: E-MEXP-3303 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

Papadopoulou Aikaterini S AS Dooley James J Linterman Michelle A MA Pierson Wim W Ucar Olga O Kyewski Bruno B Zuklys Saulius S Hollander Georg A GA Matthys Patrick P Gray Daniel H D DH De Strooper Bart B Liston Adrian A

Nature immunology 20111218 2

Thymic output is a dynamic process, with high activity at birth punctuated by transient periods of involution during infection. Interferon-α (IFN-α) is a critical molecular mediator of pathogen-induced thymic involution, yet despite the importance of thymic involution, relatively little is known about the molecular integrators that establish sensitivity. Here we found that the microRNA network dependent on the endoribonuclease Dicer, and specifically microRNA miR-29a, was critical for diminishin ...[more]

PMID: 22179202

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