MiR-21 bone marrow derived eos
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Thomas Lu
PROVIDER: E-MEXP-3346 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Targeted ablation of miR-21 decreases murine eosinophil progenitor cell growth.
Lu Thomas X TX Lim Eun-Jin EJ Itskovich Svetlana S Besse John A JA Plassard Andrew J AJ Mingler Melissa K MK Rothenberg Joelle A JA Fulkerson Patricia C PC Aronow Bruce J BJ Rothenberg Marc E ME
PloS one 20130322 3
MiR-21 is one of the most up-regulated miRNAs in multiple allergic diseases associated with eosinophilia and has been shown to positively correlate with eosinophil levels. Herein, we show that miR-21 is up-regulated during IL-5-driven eosinophil differentiation from progenitor cells in vitro. Targeted ablation of miR-21 leads to reduced eosinophil progenitor cell growth. Furthermore, miR-21(-/-) eosinophil progenitor cells have increased apoptosis as indicated by increased levels of annexin V po ...[more]
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