Transcription profiling of HeLa cells transfected with MECT1-MAML2_Targets
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yang Cao
PROVIDER: E-MEXP-340 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation.
Wu Lizi L Liu Jingxuan J Gao Ping P Nakamura Makoto M Cao Yang Y Shen Huangxuan H Griffin James D JD
The EMBO journal 20050616 13
Salivary gland tumors, a group of histologically diverse benign and malignant neoplasms, represent a challenging problem for diagnosis and treatment. A specific recurring t(11;19)(q21;p13) translocation is associated with two types of salivary gland tumors, mucoepidermoid carcinomas and Warthin's tumors. This translocation generates a fusion protein comprised of the N-terminal CREB (cAMP response element-binding protein)-binding domain of the CREB regulator MECT1 (Mucoepidermoid carcinoma transl ...[more]
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