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Transcription profiling of intramacrophage Burkholderia cenocepacia K56-2

ABSTRACT: Effect of internalization by macrophages on bacterial gene transcription in Burkholderia cenocepacia

ORGANISM(S): Burkholderia cenocepacia

SUBMITTER: Jennifer Tolman

PROVIDER: E-MEXP-3408 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global changes in gene expression by the opportunistic pathogen Burkholderia cenocepacia in response to internalization by murine macrophages.

Tolman Jennifer S JS Valvano Miguel A MA

BMC genomics 20120209

<h4>Background</h4>Burkholderia cenocepacia is an opportunistic pathogen causing life-threatening infections in patients with cystic fibrosis. The bacterium survives within macrophages by interfering with endocytic trafficking and delaying the maturation of the B. cenocepacia-containing phagosome. We hypothesize that B. cenocepacia undergoes changes in gene expression after internalization by macrophages, inducing genes involved in intracellular survival and host adaptation.<h4>Results</h4>We ex ...[more]

PMID: 22321740

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